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c/bpc157·posted 9 months ago by u/enzo_ferrari

[Discussion] pentadecapeptide is doing more work than we give it credit for

Discussion Cold Box ×4

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 12 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 20 reads it before doing the same thing.

1,079 up / 216 down83% upvoted42 commentsid 117ov827 Oct 2025

42 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/sequence_checkerresearch peptides147 points·9 months ago·edited

pentadecapeptide is sequence, the supply chain naming is a mess

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u/teodor_szabo60 points·9 months ago

Stalled for 21 weeks, changed nothing, and it started moving again on week 15.

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u/nikhil_lindqvist43 points·9 months ago

Strongly agree. Zero human controlled data.

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u/mariam_cabrera-30 points·9 months ago

near-zero controlled human data, full stop

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u/vikram_mbeki1 point·9 months ago

near-zero controlled human data, full stop

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/hplc_hobbyistruns their own column52 points·9 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/piotr_grimaldi65 points·9 months ago

regulatory status changed in 5 countries, check yours

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u/hplc_hobbyistruns their own column17 points·9 months ago

Small correction: the trial was 3 weeks, not 17. Does not change your point but people will quote it.

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u/tomas_kimani22 points·9 months ago

handlers in the community are rare and cautious

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u/mei_serrano12 points·9 months ago

Second this question. I have wondered about sequence for 18 months and never seen a straight answer.

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u/teodor_szabo16 points·9 months ago

Did anything else change in the same window?

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u/canada_coverage12 points·9 months ago

rodent data must be labelled as rodent data

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u/ahmed_iyer56 points·9 months ago

the sequence variation is the real issue

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u/mariam_cabrera20 points·9 months ago

the sequence variation is the real issue

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

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u/enzo_ferrariOP12 points·9 months ago

Ireland here. Waited 23 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/canada_coverage3 points·9 months ago

near-zero controlled human data, full stop

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u/meal_prep_mira14 points·9 months ago

This is correct. The naming is genuinely confusing.

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u/ice_pack_auditcold chain47 points·9 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/marit_sandvik33 points·9 months ago

Mechanistically the bit that matters is regulatory. It explains most of the early profile and a decent chunk of the outcome.

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u/kavya_verhoeven20 points·9 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/enzo_ferrariOP15 points·9 months ago

Week 86 for me and the honest summary is: 27kg down, sulphur burps manageable, and I have thought about food maybe four times today.

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u/tb500_tangent15 points·9 months ago

handlers in the community are rare and cautious

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u/batch_number_bertievetting7 points·9 months ago

You have restated the marketing copy. What is the actual substance here.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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