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going up faster doesn’t get you there faster, it just gets you sicker faster
Learned this one the expensive way. Went up because the scale stalled, not because I actually needed to, and all I bought myself was two rough weeks and no extra loss…
Tirzepatide
c/tirzepatide · created 9 Aug 2023
Dual GIP/GLP-1 agonism. Mounjaro, Zepbound, compounded and research tirzepatide.
Hot
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the actual arithmetic for splitting a weekly mg total into two draws, worked example
Getting DMs asking to show the math instead of just saying "split it evenly" so here's a full worked example using round numbers. Say a vial is labelled 10mg and…
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posted 4 days ago by u/nightowl_injector
[Log] eight weeks in, here’s the actual schedule and what each step felt likePosting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…
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posted 4 days ago by u/devils_advocate_d
is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properlyGenuine discussion question, not trying to be contrarian for its own sake this time. Is there an actual physiological reason weeks 4-ish tend to stall, or is it mostly…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards367
posted 5 days ago by u/customs_seizure_sid
is the tirz appetite thing actually different or am i imagining itTrying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides…
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posted 5 days ago by u/elin_varga
[Results] 5mg for eight months, never went higher, -22kgQuick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
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posted 7 days ago by u/emil_okwuosa
why is nobody talking about the SURPASS-CVOT readoutRight, the SURPASS question again, but with numbers this time. I have 22 data points over 36 weeks. The pattern is consistent enough that I do not think it is chance,…
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posted 6 days ago by u/marta_dziedzic
[Lab] SSA tirz 10mg — Janoshik 99.1%, third batch in a rowGenuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I…
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posted 10 days ago by u/kaia_cabrera
[Discussion] "tirz is stronger than sema" needs a comparator dose or it means nothingBeen lurking in c/compounding for about 21 months and finally have something worth posting. Short version: week 53, 5mg, and GIP is the bit I still cannot get a…
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posted 11 days ago by u/ferran_mensah
GIP agonism explained like i am five, pleaseRight, the Mounjaro question again, but with numbers this time. I have 13 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance,…
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posted 13 days ago by u/hana_pereira
the nausea profile at 7.5 was worse than 10 for me and i cannot explain itGenuinely asking, not being difficult. Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I…
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posted 15 days ago by u/elin_varga
[Titration] 12 weeks per step is not too slow, it is just unfashionableQuick one. Canada here. Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
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posted 17 days ago by u/titration_marshal
SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%SURMOUNT. That is the whole post, but I will justify it. Everything else people worry about in c/glp1uk is downstream of it. Titration speed, reflux, the endless dose…
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posted 19 days ago by u/discount_math_dm
anyone else find 15mg genuinely unpleasant with no extra lossRight, the SURPASS question again, but with numbers this time. I have 12 data points over 12 weeks. The pattern is consistent enough that I do not think it is chance,…
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posted 21 days ago by u/laila_wikstrom
[Trial Data] SURMOUNT-4 withdrawal arm is the scariest chart in this spaceGenuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net2.9k
posted 24 days ago by u/cormac_pereira
compounded tirz pricing has doubled in my area in four monthsQuick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
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posted 26 days ago by u/dario_vermeulen
my resting HR went from 58 to 66 on titration and settled backtirzepatide. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps,…
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posted 28 days ago by u/nordic_pricing
[Question] does the vial concentration change how much dead space costs meSomething I noticed reading old threads that I have not seen said out loud. The advice on Mounjaro in this community changed substantially around the start of last…
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posted 1 months ago by u/hana_pereira
[Vendor] QST order #9 — Spain, 31 days, no drama, receipts insideI have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
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posted 1 months ago by u/mikkel_ogunleye
the Zepbound question that gets asked weekly, answered properlyPosting this because I searched for it and got nothing useful. Setup: 5mg, week 24, constipation present but not ruining anything. I changed exactly one variable —…
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posted 1 months ago by u/tove_vasquez
[Question] how do you actually verify MounjaroConfession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks…
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posted 1 months ago by u/kaia_wojcik
[Discussion] can we stop arguing about tirzepatide until somebody posts a numberTrying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides…
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posted 1 months ago by u/search_before_post
is it normal to get sulphur burps at week 60Quick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
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posted 1 months ago by u/aksel_kjaer
[Meta] the 15mg rule is doing its job and people should stop complainingPosting this because I searched for it and got nothing useful. Setup: 12.5mg, week 16, constipation present but not ruining anything. I changed exactly one variable —…
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posted 1 months ago by u/cato_girard
[PSA] Medutest results are area% by default and people keep forgettingConfession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks…