the nausea profile at 7.5 was worse than 10 for me and i cannot explain it
Genuinely asking, not being difficult.
Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
Not convinced. The evidence does not support that reading.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Respectfully this is a sample of one presented as a finding.
SURMOUNT data is messier than STEP data but the weight loss is there
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
the 15mg is the top of the pen, not the required dose
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
That is net peptide content, not purity. Different number, different meaning.
Tried both. Sema worked, tirz worked better for me, but my nausea profile was worse on tirz.
This matches the trial data. SURMOUNT-1 was 93.7% body weight at 10 weeks.
the dual agonism hits different and that is why people describe it differently
The confident tone is doing a lot of work that the evidence is not.
stalled on sema, tried tirz, and the curves were actually different shapes
Not to be pedantic but Mounjaro and 15mg are being used interchangeably and they are not interchangeable in real life.
Not to be pedantic but Mounjaro and 15mg are being used interchangeably and they are not interchangeable in real life.
Disagree on that part. 95.1% and 97.9% on the same vial is normal.
The confident tone is doing a lot of work that the evidence is not.
Adding to this: SURPASS is doing more work than the comment implies.
Small correction: the trial was 9 weeks, not 19. Does not change your point but people will quote it.
Did the constipation feel the same as on tirz or genuinely different?
- 1The confident tone is doing a lot of work that the evidence is not.7 comments in this branch · started by u/aksel_kjaer
- 2Removed a chain here. The rule is one line long and it is not negotiable.6 comments in this branch · started by u/quiet_moderator