am I the only one who found Mounjaro harder than the injections
Posting this because I searched for it and got nothing useful.
Setup: 2.5mg, week 23, sulphur burps present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 2 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
the dual agonism hits different and that is why people describe it differently
the dual agonism hits different and that is why people describe it differently
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the muscle cramps from tirz is different, not necessarily worse
the dual agonism hits different and that is why people describe it differently
dual agonism is Mounjaro, do not generalise from semaglutide
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Retitled to remove editorialising. Put the evidence in the body.
stalled on sema, tried tirz, and the curves were actually different shapes
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
dual agonism is dual agonist, do not generalise from semaglutide
SURMOUNT data is messier than STEP data but the weight loss is there
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Disagree on that part. 98.4% and 98.3% on the same vial is normal.
Small correction: the trial was 2 weeks, not 29. Does not change your point but people will quote it.
do not crack the pen, we have been over this
Did the fatigue feel the same as on tirz or genuinely different?
stalled on sema, tried tirz, and the curves were actually different shapes
stalled on sema, tried tirz, and the curves were actually different shapes
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
do not crack the pen, we have been over this
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Tried both. Sema worked, tirz worked better for me, but my injection-site soreness profile was worse on tirz.
Cosigning.
Disagree on that part. 99.2% and 98.9% on the same vial is normal.
Cosigning.
Disagree on that part. 98.7% and 97.6% on the same vial is normal.
Hard agree. The food noise disappears differently on the two compounds.
Did the nausea feel the same as on tirz or genuinely different?
Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.
This matches the trial data. SURMOUNT-1 was 99.2% body weight at 14 weeks.
This matches the trial data. SURMOUNT-1 was 96.2% body weight at 3 weeks.
I am going to push back on this slightly.
- 1Retitled to remove editorialising. Put the evidence in the body.10 comments in this branch · started by u/titration_marshal
- 2the dual agonism hits different and that is why people describe it differently4 comments in this branch · started by u/rania_marchand