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u/georgi_chowdhury

Contributes reviews on supplier material. Based in Bologna.

member · joined 17 Aug 2025

3,246post karma
7,161comment karma
2submissions
108comments

comment on [Method] the gradient everyone uses for sema and why it under-resolves the des-amido in c/hplc · -38 points · 3 days ago

Injection volume and flow rate? Those affect resolution.

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comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · 17 points · 5 days ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 7 points · 5 days ago

You have restated the marketing copy. What is the actual substance here.

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comment on [Lab] first independent cagrilintide purity number i have seen in c/cagrilintide · 6 points · 6 days ago

amylin is not a GLP-1, posts conflating them get corrected

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comment on how do i know if my dose is working in c/newbiequestions · 20 points · 12 days ago

Slight fix: the number was 96.8, not 98.4. Decimal point, but a fairly consequential one.

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comment on [Titration] 12 weeks per step is not too slow, it is just unfashionable in c/tirzepatide · 164 points · 14 days ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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comment on SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30% in c/tirzepatide · 63 points · 15 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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comment on what does 0.25 mean, 0.25 of what in c/newbiequestions · 11 points · 15 days ago

what is bac water — bacteriostatic water, preservative included

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comment on [Lab] LC-MS confirmed identity but the UV purity is 94%. now what in c/hplc · 0 points · 15 days ago

state the method: column, gradient, detection wavelength, injection volume

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comment on [Caution] not approved anywhere. keep posts descriptive. in c/cagrilintide · 1 points · 20 days ago

REDEFINE which arm?

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comment on method development — 10 things I got wrong before I got it right in c/hplc · 37 points · 27 days ago

Injection volume and flow rate? Those affect resolution.

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comment on why do people talk about units and mg like they are different things in c/newbiequestions · 22 points · 29 days ago

week two nothing happening — yes, that is normal

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comment on small win: satiety stopped being a problem at week 75 in c/cagrilintide · 4 points · 1 months ago

Yeah, amylin is doing different work than GLP-1.

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comment on [Question] how do you actually verify amylin in c/cagrilintide · 36 points · 1 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does CagriSema.

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comment on does gradient actually matter or is it forum lore at this point in c/hplc · 57 points · 1 months ago

chromatogram or it did not happen

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comment on [Discussion] can we stop arguing about SURMOUNT until somebody posts a number in c/tirzepatide · 53 points · 1 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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comment on small win: GIP stopped being a problem at week 31 in c/tirzepatide · 18 points · 1 months ago

do not crack the pen, we have been over this

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comment on small win: GIP stopped being a problem at week 31 in c/tirzepatide · 25 points · 1 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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comment on pharmacology is the most under-discussed thing in c/glp1women in c/glp1science · 3 points · 2 months ago

cite the paper: journal, year, first author, links optional

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comment on [Discussion] Janoshik is doing more work than we give it credit for in c/labresults · -4 points · 2 months ago

the VendorInvestigate and Medutest results differ by 3 points, both inside inter-lab variance

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