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c/tirzepatide·posted 1 months ago by u/crosspost_bot_no

[Discussion] can we stop arguing about SURMOUNT until somebody posts a number

Discussion Long Haul ×5 Well Actually ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking SURMOUNT against eGFR for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

1,578 up / 322 down83% upvoted13 commentsid ooio8w5 Jun 2026

13 comments

2 in this archive, depth 1

best — the order this archive was captured in

u/tarek_kirchner93 points·1 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/georgi_chowdhury53 points·1 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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