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c/tirzepatide·posted 2 years ago by u/throwaway_wl2026

GIP: the version I wish someone had shown me in week 1

Trial Data Cold Box ×4 The Quiet One ×2 Well Actually ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything.

What would actually settle it is 39 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

16,277 up / 1,470 down92% upvoted13 commentsid 13g8ky10 Nov 2023

13 comments

6 in this archive, depth 4

best — the order this archive was captured in

u/tarek_lokken2.2k points·2 years ago

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/bastian_eriksen-38 points·2 years ago

the muscle cramps from tirz is different, not necessarily worse

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u/copay_card_cc1 point·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/cato_girard1 point·2 years ago

do not crack the pen, we have been over this

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u/britt_okwuosa1 point·2 years ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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u/quiet_moderatormod1.3k points·2 years ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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