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c/tirzepatide·submitted 2 years ago by u/throwaway_wl2026

GIP: the version I wish someone had shown me in week 1

Trial Databranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything. What would actually settle it is 39 people measuring the same…

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5 comments, started 2 years ago
u/tarek_lokken2.2k points·2 years ago

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/bastian_eriksen-38 points·2 years ago

the muscle cramps from tirz is different, not necessarily worse

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u/copay_card_cc1 point·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/cato_girard1 point·2 years ago

do not crack the pen, we have been over this

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u/britt_okwuosa1 point·2 years ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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