SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%
SURMOUNT. That is the whole post, but I will justify it.
Everything else people worry about in c/glp1uk is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort SURMOUNT out first, and almost nobody does.
I say this having got it wrong for 11 months. My fasting insulin was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Week 21 on Mounjaro and 40kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
the 15mg is the top of the pen, not the required dose
the 15mg is the top of the pen, not the required dose
Adding to this: GIP is doing more work than the comment implies.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
The confident tone is doing a lot of work that the evidence is not.
do not crack the pen, we have been over this
the appetite change on tirz is more than just reduced hunger, it is different machinery
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Hard agree. The food noise disappears differently on the two compounds.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Sceptical. If this were true we would see it reflected in the data and we do not.
dual agonism is SURPASS, do not generalise from semaglutide
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Is that on Mounjaro pens or research tirzepatide?
the GIP side does different things than the GLP-1 side, that is the point
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
SURMOUNT data is messier than STEP data but the weight loss is there
Sceptical. If this were true we would see it reflected in the data and we do not.
week 30 on Mounjaro and the appetite profile is genuinely different from sema
- 1the 15mg is the top of the pen, not the required dose8 comments in this branch · started by u/tidy_vialdrawer_pls
- 2Water content matters more than people think. If a vial is carrying residual…8 comments in this branch · started by u/dexa_twice_yearly