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Single comment threadYou are looking at one branch of SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30% — 62 comments in the full submission. View in context.
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c/tirzepatide·submitted 17 days ago by u/titration_marshal

SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%

Discussionbranch of 8 comments

SURMOUNT. That is the whole post, but I will justify it. Everything else people worry about in c/glp1uk is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort SURMOUNT out first, and almost nobody does. I say this having got it wrong for 11 months. My fasting…

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8 comments, started 16 days ago
u/tidy_vialdrawer_pls137 points·16 days ago

the 15mg is the top of the pen, not the required dose

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u/quiet_moderatormod35 points·16 days ago

the 15mg is the top of the pen, not the required dose

Adding to this: GIP is doing more work than the comment implies.

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u/dexa_twice_yearlyMOD78 points·16 days ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/dario_vermeulen40 points·16 days ago

The confident tone is doing a lot of work that the evidence is not.

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u/ignacio_vanhecke19 points·16 days ago·edited

do not crack the pen, we have been over this

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u/gustav_vermeulen0 points·16 days ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/aksel_kjaer-6 points·15 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/teodor_szabo21 points·16 days ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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