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[Meta] the 15mg rule is doing its job and people should stop complaining
Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 16, constipation present but not ruining anything. I changed exactly one variable —…
u/aksel_kjaer
Contributes reviews on supplier material. Based in Ghent.
member · joined 12 Mar 2025
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comment on TB-500 and Thymosin Beta-4 are not the same product and vendors know that in c/researchpeptides · 17 points · 4 days ago
Which country? Half the answers in this thread only apply in the Netherlands.
comment on [Lab] sequence check before price check. every time. in c/researchpeptides · 15 points · 4 days ago
Titration speed is a side-effect dial far more than an efficacy dial.
comment on [Correction] you cannot report area% to two decimals off that baseline in c/hplc · 14 points · 7 days ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on [Paper] ACHIEVE-1 glycaemic data vs the injectables in c/orforglipron · 18 points · 10 days ago
cite ATTAIN/ACHIEVE arms specifically
comment on the nausea profile at 7.5 was worse than 10 for me and i cannot explain it in c/tirzepatide · 8 points · 11 days ago
Did the constipation feel the same as on tirz or genuinely different?
comment on [Data] BIA vs DEXA on the same day, 6% apart, pick a method and stay with it in c/glp1muscle · 2 points · 12 days ago
Respectfully this is a sample of one presented as a finding.
comment on the nausea profile at 7.5 was worse than 10 for me and i cannot explain it in c/tirzepatide · 55 points · 12 days ago
The confident tone is doing a lot of work that the evidence is not.
comment on SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30% in c/tirzepatide · -6 points · 15 days ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on retention time shifted 0.4 min and nobody wants to talk about it in c/hplc · 26 points · 18 days ago
Slight fix: the number was 97.2, not 97.4. Decimal point, but a fairly consequential one.
comment on anyone else find 15mg genuinely unpleasant with no extra loss in c/tirzepatide · 13 points · 19 days ago
Tried both. Sema worked, tirz worked better for me, but my constipation profile was worse on tirz.
comment on [Discussion] oral GLP-1 is doing more work than we give it credit for in c/orforglipron · -16 points · 20 days ago
the supply conversation changes if this approves
comment on compounded tirz pricing has doubled in my area in four months in c/tirzepatide · 197 points · 22 days ago
nobody says this and everybody needs to hear it
comment on what changed for me between week 15 and week 64 in c/researchpeptides · 21 points · 24 days ago
Mechanistically the bit that matters is handling. It explains most of the early profile and a decent chunk of the outcome.
comment on genuine question about protein that I am slightly embarrassed to ask in c/glp1muscle · 3 points · 28 days ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 15 points · 1 months ago
dual agonism is Mounjaro, do not generalise from semaglutide
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 29 points · 1 months ago
the dual agonism hits different and that is why people describe it differently
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 49 points · 1 months ago
You have restated the marketing copy.
Yes, exactly this, and it is the bit that took me 23 weeks to accept.
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 29 points · 1 months ago
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
comment on my A1c moved and I cannot work out whether method development is why in c/hplc · 9 points · 1 months ago
Yeah, the chromatogram profile matters more than the headline number.