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c/tirzepatide·submitted 17 days ago by u/titration_marshal

SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%

Discussionbranch of 8 comments

SURMOUNT. That is the whole post, but I will justify it. Everything else people worry about in c/glp1uk is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort SURMOUNT out first, and almost nobody does. I say this having got it wrong for 11 months. My fasting…

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8 comments, started 15 days ago
u/dexa_twice_yearlybody comp76 points·15 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/cato_girard20 points·15 days ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/titration_marshalOPmod · c/semaglutide0 points·15 days ago

Hard agree. The food noise disappears differently on the two compounds.

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u/titration_marshalOPmod · c/semaglutide43 points·15 days ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/georgi_chowdhury63 points·15 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/tarek_kirchner12 points·15 days ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/laila_yilmaz21 points·15 days ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/line_petrov7 points·14 days ago

Is that on Mounjaro pens or research tirzepatide?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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