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c/cagrilintide·posted 1 months ago by u/ravi_sandvik

[Question] how do you actually verify amylin

Question Cold Box ×7

Been lurking in c/orforglipron for about 18 months and finally have something worth posting.

Short version: week 28, 12.5mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 5 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 34.

1,339 up / 472 down74% upvoted34 commentsid hbzwxj16 Jun 2026

34 comments

26 in this archive, depth 4

best — the order this archive was captured in

u/yannick_salinas144 points·1 months ago
i wish i had read this 10 months ago
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u/incretin_ivypharmacology116 points·1 months ago

REDEFINE readouts are phase 23 data

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u/hugo_pires57 points·1 months ago

Strongly agree. REDEFINE is phase 21, not final.

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u/ilias_kaufmann138 points·1 months ago

the mechanism is different, the side effect profile reflects it

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u/zaid_grimaldi74 points·1 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/amara_kuipers110 points·1 months ago

Not convinced. The evidence does not support that reading.

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u/plain_titration91 points·1 months ago

amylin receptor distribution is different from GLP-1

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u/runa_grimaldi0 points·1 months ago

This is correct. The co-agonism is real.

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u/teodor_lokken1 point·1 months ago·edited

REDEFINE which arm?

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u/ravi_sandvik1 point·1 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/ravi_sandvikOP1 point·1 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/forest_plot_fionastats53 points·1 months ago

This is correct. The co-agonism is real.

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u/zeynep_ndiaye36 points·1 months ago

Are we talking amylin or GLP-1 here?

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u/sten_rautio36 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/laila_dumitru-7 points·1 months ago

the mechanism is different, the side effect profile reflects it

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u/andres_dahlberg35 points·1 months ago

amylin is not a GLP-1, posts conflating them get corrected

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u/runa_pires28 points·1 months ago·edited

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does amylin.

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u/ravi_sandvikOP11 points·1 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/runa_pires19 points·1 months ago

REDEFINE phase 15 readouts are interesting but 15 person cagrilintide is different from 15 trial cagrilintide.

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u/chidi_yilmaz9 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/ravi_sandvikOP7 points·1 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/tomas_kimani6 points·1 months ago

amylin receptor distribution is different from GLP-1

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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