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c/cagrilintide·posted 2 years ago by u/plain_titration

the amylin thing finally clicked for me and I want to write it down

Trial Data Sourced ×4 Slow Clap ×3 Receipts ×2

Genuinely asking, not being difficult.

Everyone in c/hplc repeats that satiety is important. I believe it, but I have never seen anyone show why, and when I search I get 24 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

3,505 up / 369 down90% upvoted28 commentsid 1coc6p30 Mar 2024

28 comments

21 in this archive, depth 3

best — the order this archive was captured in

u/zeynep_duarte523 points·2 years ago

Yeah, amylin is doing different work than GLP-1.

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u/ledger_modMOD265 points·2 years ago·edited

Retitled to remove editorialising. Put the evidence in the body.

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u/lipid_panel_larrybloodwork179 points·2 years ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does cagrilintide.

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u/tomas_kimani58 points·2 years ago

The satiety on amylin analogs is described as physically different.

Adding to this: REDEFINE is doing more work than the comment implies.

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u/mateusz_adebayo142 points·2 years ago

tendon and cagrilintide literature in rodents is interesting

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u/iman_castellanos-26 points·2 years ago

Rodent or human data?

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u/plain_titrationOP1 point·2 years ago

REDEFINE phase 5 readouts are interesting but 5 person satiety is different from 5 trial satiety.

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u/zeynep_weiss215 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/plain_titrationOP135 points·2 years ago

REDEFINE phase 19 readouts are interesting but 19 person cagrilintide is different from 19 trial cagrilintide.

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[removed]87 points·2 years ago

[removed by moderator]

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u/ice_pack_auditcold chain46 points·2 years ago

not approved anywhere, keep posts descriptive, not instructional

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u/emil_agyeman31 points·2 years ago

Rodent or human data?

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u/crosspost_bot_no69 points·2 years ago

the amylin agonist pool is small, community is satiety

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u/nadia_bakker134 points·2 years ago

Yeah, amylin is doing different work than GLP-1.

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u/nadia_bakker160 points·2 years ago

Are we talking amylin or GLP-1 here?

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u/plain_titrationOP61 points·2 years ago

amylin receptor distribution is different from GLP-1

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u/ferritin_low45 points·2 years ago

Are we talking amylin or GLP-1 here?

Adding to this: CagriSema is doing more work than the comment implies.

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u/tomas_kimani109 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/plain_titration0 points·2 years ago

Small correction: the trial was 17 weeks, not 32. Does not change your point but people will quote it.

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u/ms_fragmenter1 point·2 years ago

the mechanism is different, the side effect profile reflects it

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u/erez_perrin1 point·2 years ago

amylin is not a GLP-1, posts conflating them get corrected

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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