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c/cagrilintide·posted 2 years ago by u/clara_weiss

unpopular opinion: CagriSema is massively overrated

Caution Clean Column ×7 Slow Clap ×3 Receipts ×2

Something I noticed reading old threads that I have not seen said out loud.

The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

4,152 up / 1,249 down77% upvoted48 commentsid d5wf1111 Feb 2024

48 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/plain_titration200 points·2 years ago
nobody says this and everybody needs to hear it
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u/clara_weissOP-25 points·2 years ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does CagriSema.

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u/noor_hovland1 point·2 years ago

The satiety on amylin analogs is described as physically different.

Adding to this: satiety is doing more work than the comment implies.

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u/rania_marchand1 point·2 years ago

long-acting amylin is CagriSema, different satiety profile

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u/clara_weissOP1 point·2 years ago

long-acting amylin is amylin, different satiety profile

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u/tomas_kimani0 points·2 years ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does REDEFINE.

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u/declared_value_dv126 points·2 years ago

Are we talking amylin or GLP-1 here?

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u/rekha_mwangi53 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/zeynep_ndiaye35 points·2 years ago

This is correct. The co-agonism is real.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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