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c/cagrilintide·submitted 1 months ago by u/ravi_sandvik

[Question] how do you actually verify amylin

Questionbranch of 6 comments

Been lurking in c/orforglipron for about 18 months and finally have something worth posting. Short version: week 28, 12.5mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 5 threads, and the answers split roughly down the middle. What I actually want to know…

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6 comments, started 1 months ago
u/incretin_ivypharmacology116 points·1 months ago

REDEFINE readouts are phase 23 data

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u/hugo_pires57 points·1 months ago

Strongly agree. REDEFINE is phase 21, not final.

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u/ilias_kaufmann138 points·1 months ago

the mechanism is different, the side effect profile reflects it

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u/zaid_grimaldi74 points·1 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/amara_kuipers110 points·1 months ago

Not convinced. The evidence does not support that reading.

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u/plain_titration91 points·1 months ago

amylin receptor distribution is different from GLP-1

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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