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Single comment threadYou are looking at one branch of the nausea profile at 7.5 was worse than 10 for me and i cannot explain it — 54 comments in the full submission. View in context.
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c/tirzepatide·submitted 13 days ago by u/hana_pereira

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it

Trial Databranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it has…

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7 comments, started 12 days ago
u/aksel_kjaer55 points·12 days ago

The confident tone is doing a lot of work that the evidence is not.

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u/hana_pereiraOP39 points·12 days ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/swirl_dont_shakereconstitution22 points·12 days ago

Not to be pedantic but Mounjaro and 15mg are being used interchangeably and they are not interchangeable in real life.

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u/hana_pereiraOP17 points·11 days ago

Not to be pedantic but Mounjaro and 15mg are being used interchangeably and they are not interchangeable in real life.

Disagree on that part. 95.1% and 97.9% on the same vial is normal.

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u/ghrp_history38 points·12 days ago·edited

The confident tone is doing a lot of work that the evidence is not.

Adding to this: SURPASS is doing more work than the comment implies.

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u/hana_pereiraOP0 points·11 days ago

Small correction: the trial was 9 weeks, not 19. Does not change your point but people will quote it.

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u/aksel_kjaer8 points·11 days ago

Did the constipation feel the same as on tirz or genuinely different?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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