[Discussion] can we stop arguing about tirzepatide until somebody posts a number
Trying to settle this properly because the thread from last year went in circles.
The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything.
What would actually settle it is 3 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
How long at each step before you escalated?
SURMOUNT data is messier than STEP data but the weight loss is there
week 88 on Mounjaro and the appetite profile is genuinely different from sema
the nausea from tirz is different, not necessarily worse
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the 15mg is the top of the pen, not the required dose
dual agonism is Mounjaro, do not generalise from semaglutide
Week 63 on Mounjaro and 34kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the GIP side does different things than the GLP-1 side, that is the point
SURMOUNT data is messier than STEP data but the weight loss is there
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
do not crack the pen, we have been over this
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
the 15mg is the top of the pen, not the required dose
Strongly agree.
Adding to this: Mounjaro is doing more work than the comment implies.
week 76 on Mounjaro and the appetite profile is genuinely different from sema
week 76 on Mounjaro and the appetite profile is genuinely different from sema
Yes, exactly this, and it is the bit that took me 24 weeks to accept.
the appetite change on tirz is more than just reduced hunger, it is different machinery
That is net peptide content, not purity. Different number, different meaning.
Retitled to remove editorialising. Put the evidence in the body.
- 1Strongly agree. Tirz is better than sema is not a claim without a comparator…9 comments in this branch · started by u/piotr_nascimento
- 2week 88 on Mounjaro and the appetite profile is genuinely different from sema6 comments in this branch · started by u/certified_reference