u/ingrid_correia

Strongly agree. Pricing is local.

apotheke, receta, pharmacy — twenty-seven different answers

do not crack the pen, we have been over this

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Zepbound and Mounjaro are literally the same drug, the name is the only difference

the constipation from tirz is different, not necessarily worse

metformin combo is standard

Adding to this: metformin is doing more work than the comment implies.

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

week 76 on Mounjaro and the appetite profile is genuinely different from sema

Yes, exactly this, and it is the bit that took me 24 weeks to accept.

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Which country? Rules differ.

do not crack the pen, we have been over this

Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.

Strongly agree. Central appetite is real but people overstate it.

Yeah, the incretin mechanism is doing the work here.

This is correct.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

The dual agonism story is real. The appetite is physically different from semaglutide alone.

How long at each step before you escalated?

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

Week 20 on Mounjaro and 36kg down. The appetite reduction feels different from sema in ways I do not have words for yet.