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226
c/tirzepatide·posted 4 months ago by u/ingrid_correia

stalled for 16 weeks at 7.5mg and I refuse to panic this time

Titration

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking SURMOUNT against triglycerides for 33 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

234 up / 8 down97% upvoted26 commentsid 1s34jq8 Mar 2026

26 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/customs_seizure_sid-18 points·4 months ago
came here to say exactly this
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u/thyroid_tangent17 points·4 months ago

the GIP side does different things than the GLP-1 side, that is the point

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[deleted]7 points·4 months ago

[deleted]

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u/gentle_correctionnice about it13 points·4 months ago

Respectfully this is a sample of one presented as a finding.

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u/zeynep_ndiaye9 points·4 months ago

Switched from sema at 10mg to tirz at 2.5mg. Different drugs, cannot compare the doses directly.

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u/priya_guerrero4 points·4 months ago

My A1c moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/yusuf_ramos3 points·4 months ago

dual agonism is dual agonist, do not generalise from semaglutide

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u/britt_okwuosa1 point·4 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/ingrid_correiaOP1 point·4 months ago

do not crack the pen, we have been over this

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u/b12_baseline6 points·4 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/ingrid_correiaOP3 points·4 months ago

Week 20 on Mounjaro and 36kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/titration_marshalmod · c/semaglutide4 points·4 months ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 9 weeks.

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u/ingrid_correiaOP2 points·4 months ago

You have restated the marketing copy. What is the actual substance here.

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u/bastian_ekstrom1 point·4 months ago

the nausea from tirz is different, not necessarily worse

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u/sten_bhattacharya1 point·4 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/halima_boateng0 points·4 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/throwaway_wl20261 point·4 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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