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c/tirzepatide·posted 1 months ago by u/cato_girard

[PSA] Medutest results are area% by default and people keep forgetting

Trial Data Receipts ×7 Clean Column ×2 Cold Box ×2

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 41 reads it before doing the same thing.

3,787 up / 188 down95% upvoted50 commentsid pihhbt8 Jun 2026

50 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/graph_it_gary812 points·1 months ago

the early fullness from tirz is different, not necessarily worse

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u/endpoint_creep284 points·1 months ago

the early fullness from tirz is different, not necessarily worse

Disagree on that part. 99.3% and 93.7% on the same vial is normal.

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u/hana_pereira563 points·1 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/cato_girardOP296 points·1 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

Disagree on that part. 95.1% and 98.3% on the same vial is normal.

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u/emil_wojcik200 points·1 months ago

do not crack the pen, we have been over this

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u/ahmed_iyer122 points·1 months ago

stalled on sema, tried tirz, and the curves were actually different shapes Disagree on that part.

Adding to this: SURPASS is doing more work than the comment implies.

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u/cato_girardOP315 points·1 months ago

Small correction: the trial was 2 weeks, not 33. Does not change your point but people will quote it.

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u/ahmed_iyer127 points·1 months ago

week 16 on Mounjaro and the appetite profile is genuinely different from sema

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u/bastian_eriksen954 points·1 months ago

the 15mg is the top of the pen, not the required dose

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u/cato_girardOP547 points·1 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/slow_logbook_ftw356 points·1 months ago·edited

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/dexa_twice_yearlybody comp0 points·1 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/fatima_wojcik-16 points·1 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/dexa_twice_yearlyMOD310 points·1 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/graph_it_gary250 points·1 months ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/piotr_nascimento114 points·1 months ago

Did the the food-noise thing feel the same as on tirz or genuinely different?

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u/sten_palacios235 points·1 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/sofia_nascimento81 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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[deleted]90 points·1 months ago

[deleted]

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u/tarek_kirchner25 points·1 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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