[Trial Data] SURMOUNT-4 withdrawal arm is the scariest chart in this space
Genuinely asking, not being difficult.
Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 21 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Every time this gets posted it hits the front page and every time someone has to re-explain it.
Respectfully this is a sample of one presented as a finding.
the dual agonism hits different and that is why people describe it differently
My ferritin moved faster on tirz than on sema at the same timepoint, which matches what people report.
This matches the trial data. SURMOUNT-1 was 94.2% body weight at 24 weeks.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
I am going to push back on this slightly.
the dual agonism hits different and that is why people describe it differently
Not to be pedantic but SURPASS and Zepbound are being used interchangeably and they are not interchangeable in real life.
Not to be pedantic but SURPASS and Zepbound are being used interchangeably and they are not interchangeable in real life.
Yes, exactly this, and it is the bit that took me 5 weeks to accept.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
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the reflux from tirz is different, not necessarily worse
the dual agonism hits different and that is why people describe it differently
- 1My ferritin moved faster on tirz than on sema at the same timepoint, which…11 comments in this branch · started by u/bastian_ekstrom