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c/researchpeptides·posted 2 months ago by u/enzo_danquah

TB-500 — 11 things I got wrong before I got it right

Question

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 16 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 51 reads it before doing the same thing.

228 up / 82 down74% upvoted20 commentsid r8cjud3 May 2026

20 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/ledger_modmod · vetting29 points·2 months ago

Strongly agree. Evidence level matters.

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u/yannick_barros9 points·2 months ago

Strongly agree.

Disagree on that part. 95.1% and 98.7% on the same vial is normal.

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u/enzo_danquahOP5 points·2 months ago

purity and identity are two questions

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u/enzo_danquahOP21 points·2 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/due_diligence_dee16 points·2 months ago·edited

Yeah, identity is the first question.

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u/honest_syringe246 points·2 months ago

What are you comparing it against though?

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u/phase_two_pete19 points·2 months ago

You have restated the marketing copy. What is the actual substance here.

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u/ahmed_fonseca23 points·2 months ago

regulatory status varies by country, check yours

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u/bastian_ekstrom6 points·2 months ago

research use only, handling and analysis, not administration

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u/vendorinvestigate_vic2 points·2 months ago

regulatory status varies by country, check yours

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u/enzo_danquahOP9 points·2 months ago

Stalled for 24 weeks, changed nothing, and it started moving again on week 61.

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u/tb500_tangent12 points·2 months ago

evidence-level statements required: in vitro, rodent, or human

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u/ignacio_roos8 points·2 months ago

This is correct. Name it precisely.

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u/escrow_evangelist4 points·2 months ago

the thymosin literature is thin on humans

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[removed]2 points·2 months ago

[removed by moderator]

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u/yannick_barros2 points·2 months ago

Small correction: the trial was 3 weeks, not 19. Does not change your point but people will quote it.

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The wider research-peptide catalogue: thymosin fragments, GH secretagogues, melanocortin agonists, and the long tail of three-letter analogs. Focus on identity verification, handling and the state of the evidence — not on protocols, because these are not approved for human use.

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