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c/coldchain·posted 1 year ago by u/isabela_nilsen

is it normal to get nausea at week 30

Question Receipts ×1 Slow Clap ×2 Cold Box ×3

Right, the cold chain question again, but with numbers this time.

I have 3 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 14, not week 63. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

3,223 up / 532 down86% upvoted66 commentsid qx3cs522 Oct 2024

66 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/kian_solberg444 points·1 year ago·edited

time-at-temperature integral is the dose, not just peak temperature

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u/coldchain_karenMOD235 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/analog_alphabet408 points·1 year ago

This is correct. Dry powder is way more robust than liquid.

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u/cesar_teixeira168 points·1 year ago

lyophilised powder is far more forgiving than reconstituted solution

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u/marta_ilunga60 points·1 year ago

lyophilised powder is far more forgiving than reconstituted solution

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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u/fatima_yildiz101 points·1 year ago

Disagree. What you are describing is consistent with cold chain, not with what you concluded.

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u/maren_sorensen197 points·1 year ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/prior_auth_painappeals0 points·1 year ago

I am going to push back on this slightly.

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u/bence_ibarra1 point·1 year ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/prior_auth_painappeals1 point·1 year ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

Adding to this: packaging is doing more work than the comment implies.

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u/fatima_yildiz1 point·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/isabela_nilsenOP1 point·1 year ago

lyophilised powder is far more forgiving than reconstituted solution

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u/certified_referenceQC177 points·1 year ago

the logger trace is the data that matters, not the packaging promises

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u/split_dose_sceptic49 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/transit_variance15 points·1 year ago·edited

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/appeal_letter_al37 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

Disagree on that part. 95.1% and 96.2% on the same vial is normal.

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u/salma_vasquez13 points·1 year ago

no tracking numbers, no full addresses, no label photos — instant removal

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u/plain_titration_2024140 points·1 year ago

Poland to Poland takes 16 days on average, variance is 35 days

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u/nightowl_injector87 points·1 year ago

lane reports need origin, destination, carrier, and actual transit days

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u/aleksi_eriksen77 points·1 year ago

Yeah, data logger is the only acceptable proof.

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u/milos_vestergaard23 points·1 year ago·edited

no tracking numbers, no full addresses, no label photos — instant removal

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u/ewan_tulloch7 points·1 year ago·edited

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/sequence_checkerresearch peptides-16 points·1 year ago

Strongly agree. Peak temperature is not the whole story.

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u/bence_ibarra4 points·1 year ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/meera_sandvik6 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/anders_karlsen2 points·1 year ago·edited

Do you have the logger trace?

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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c/coldchain rules
  1. Excursion claims need a logger trace or a photo taken at unboxing. "It felt warm" is not data.
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