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c/glp1canada·posted 8 months ago by u/food_noise_gone

reading Canada threads from 2024 and half of it aged badly

Formulary The Quiet One ×9 Sourced ×2

Posting this because I searched for it and got nothing useful.

Setup: 12.5mg, week 46, constipation present but not ruining anything. I changed exactly one variable — province — and tracked it for 7 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

1,304 up / 88 down94% upvoted63 commentsid gm2zcu27 Nov 2025

63 comments

26 in this archive, depth 4

best — the order this archive was captured in

u/dose_diary_danalog keeper207 points·8 months ago·edited

Half-life is about 168 hours, so steady state lands around week 6–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/ravi_bergstrom181 points·8 months ago
yep. 20 weeks in, same.
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u/incretin_ivypharmacology142 points·8 months ago
this should be in the wiki
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u/pavel_kravchenko116 points·8 months ago

public coverage status differs

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u/sequence_checkerresearch peptides71 points·8 months ago

Not to be pedantic but formulary and Canada are being used interchangeably and they are not interchangeable in real life.

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u/anders_karlsen0 points·8 months ago

public coverage status differs

Disagree on that part. 98.7% and 99.3% on the same vial is normal.

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u/food_noise_goneOPmaintenance109 points·8 months ago

You have restated the marketing copy. What is the actual substance here.

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u/mariam_mensa34 points·8 months ago

You have restated the marketing copy.

Yes, exactly this, and it is the bit that took me 17 weeks to accept.

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u/food_noise_goneOPmaintenance60 points·8 months ago

Came off after 23 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/isabela_guerrero62 points·8 months ago

provincial formularies differ sharply

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u/ahmed_rasmussen42 points·8 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/anders_karlsen26 points·8 months ago

the Spain answer is not the Spain answer

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u/ignacio_silva68 points·8 months ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/canada_coverageMOD33 points·8 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/zeynep_ndiaye22 points·8 months ago

Flair changed to match the content.

Adding to this: special authorization is doing more work than the comment implies.

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u/food_noise_goneOPmaintenance14 points·8 months ago

the 16 province variation is real

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u/samir_falk17 points·8 months ago

the the Netherlands answer is not the the Netherlands answer

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u/gradient_goblin17 points·8 months ago

Yeah, Canada coverage is not Canada coverage.

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u/milos_vestergaard21 points·8 months ago·edited

Strongly agree. Provincial variation is real.

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u/kavya_kravchenko0 points·8 months ago

the 5 province variation is real

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u/ayesha_radich1 point·8 months ago

You have restated the marketing copy. What is the actual substance here.

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u/anya_antonsen-31 points·8 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/dario_vermeulen1 point·8 months ago

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/kaia_fonseca1 point·8 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/zaid_grimaldi1 point·8 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/spreadsheet_gremlindata1 point·8 months ago

the Spain answer is not the Spain answer

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Canadian access: provincial formulary differences, private plan coverage, the special-authorisation process, cross-border pricing arbitrage and why the Ontario answer is not the Alberta answer.

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