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c/glp1science·submitted 4 days ago by u/niels_roos

[Explainer] delayed gastric emptying does most of the work people credit to the brain

Explainerbranch of 8 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that incretin is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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8 comments, started 3 days ago
u/enzo_danquah2 points·3 days ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/niels_roosOP1 point·2 days ago

This is correct. Rodent data is investigational, not predictive.

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u/farid_kuipers1 point·2 days ago

do not extrapolate rodent data to human dosing without saying so

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u/sig_figs_sammod · analytical1 point·2 days ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/niels_roos1 point·2 days ago

the half-life is incretin, affects steady state timing

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u/plain_titration1 point·2 days ago

the 3-day half-life means week 3 is still ramp-up pharmacokinetically

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u/nadia_fonseca1 point·2 days ago

Yeah, the incretin mechanism is doing the work here.

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u/gastric_emptying_g1 point·1 days ago

central appetite signalling is real but people overweight it

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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