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c/glp1science·submitted 4 days ago by u/niels_roos

[Explainer] delayed gastric emptying does most of the work people credit to the brain

Explainerbranch of 5 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that incretin is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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5 comments, started 4 days ago
u/employer_carveout-35 points·4 days ago

Is that mechanism or speculation?

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u/not_my_main_nm1 point·4 days ago

Strongly agree. Central appetite is real but people overstate it.

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u/elodie_grimaldi1 point·3 days ago·edited

Is that mechanism or speculation?

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u/sig_figs_sammod · analytical1 point·3 days ago·edited

Yeah, the incretin mechanism is doing the work here.

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u/niels_roosOP1 point·4 days ago

Stomach physiology changed when I moved up to 2.4mg. Gastric emptying lag is the whole story.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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