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c/glp1science·submitted 1 year ago by u/second_week_sceptic

what changed for me between week 35 and week 84

Paperbranch of 4 comments

Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything. What would actually settle it is 27 people measuring the same…

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4 comments, started 1 year ago
u/ireland_drugs_pay367 points·1 year ago

Mechanistically the bit that matters is half-life. It explains most of the early profile and a decent chunk of the outcome.

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u/second_week_scepticOP270 points·1 year ago

central appetite signalling is real but people overweight it

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u/whois_wanda203 points·1 year ago

central appetite signalling is real but people overweight it

Disagree on that part. 97.4% and 98.3% on the same vial is normal.

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u/yannick_barros0 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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