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crossposted from c/researchpeptides by u/anders_osei — [Question] how do you actually verify handling
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c/glp1science·posted 1 year ago by u/slow_logbook

[Meta] proposal — a flair for appetite posts

Discussion Long Haul ×9

Week 51 update. 22kg down from the start, muscle cramps basically gone since about week 8.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

789 up / 203 down80% upvoted10 commentsid 1t0dv230 Mar 2025

10 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/aksel_palacios104 points·1 year ago
no
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u/viktor_girard-32 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/slow_logbook37 points·1 year ago

Disagree. What you are describing is consistent with gastric emptying, not with what you concluded.

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u/slow_logbookOP26 points·1 year ago

gastric emptying is real and explains most early the food-noise thing

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u/bastian_ekstrom23 points·1 year ago

glucagon-receptor contribution is mechanism for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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