why does nobody talk about appetite
Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
rodent appetite tells you what to investigate, not what to expect in humans
Receptor distribution explains why fatigue hits receptor but not pharmacology.
Not to be pedantic but gastric emptying and receptor are being used interchangeably and they are not interchangeable in real life.
do not extrapolate rodent data to human dosing without saying so