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c/glp1science·submitted 2 years ago by u/yusuf_ramos

incretin: the version I wish someone had shown me in week 1

Discussionbranch of 6 comments

Right, the mechanism question again, but with numbers this time. I have 21 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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6 comments, started 2 years ago
u/amara_dziedzic56 points·2 years ago

The receptor literature is interesting but rodent models do not scale linearly to human dosing.

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u/incretin_ivyMOD29 points·2 years ago·edited

Tracking number removed. It identifies both ends of a shipment.

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u/tomas_lundgren23 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

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u/priya_guerrero19 points·2 years ago·edited

Which paper are you quoting?

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u/zeynep_villalobos15 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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[deleted]6 points·2 years ago

[deleted]

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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