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c/glp1science·submitted 2 years ago by u/maintenance_mode_max

genuine question about receptor that I am slightly embarrassed to ask

Needs Sourcebranch of 5 comments

Posting this because I searched for it and got nothing useful. Setup: 10mg, week 27, constipation present but not ruining anything. I changed exactly one variable — receptor — and tracked it for 10 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…

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5 comments, started 2 years ago
u/asks_dumb_questions83 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/incretin_ivypharmacology51 points·2 years ago

Stomach physiology changed when I moved up to 12.5mg. Gastric emptying lag is the whole story.

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u/yusuf_ramos55 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/bilal_osei44 points·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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