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c/glp1science·submitted 1 year ago by u/titration_marshal

[Discussion] we are measuring appetite at the wrong time and calling it noise

Discussionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: incretin matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 5 people measuring the same…

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6 comments, started 1 year ago
u/zeynep_villalobos57 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/titration_marshalOPmod · c/semaglutide67 points·1 year ago

Rodent, human, or in vitro?

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u/hedda_adeyemi31 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/annika_fonseca23 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/titration_marshalOPmod · c/semaglutide-28 points·1 year ago

The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.

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u/annika_fonseca1 point·1 year ago

receptor distribution matters, GLP-1 is not everywhere

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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