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c/glp1science·submitted 6 months ago by u/karma_irrelevant

reading receptor threads from 2024 and half of it aged badly

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Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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4 comments, started 6 months ago
u/fatima_kowalski275 points·6 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/rasmus_kimani132 points·6 months ago

Receptor distribution explains why fatigue hits pharmacology but not receptor.

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u/karma_irrelevantOP103 points·6 months ago

Stomach physiology changed when I moved up to 1.7mg. Gastric emptying lag is the whole story.

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u/marisol_kravchenko26 points·6 months ago

Not to be pedantic but receptor and incretin are being used interchangeably and they are not interchangeable in real life.

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