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c/glp1science·submitted 6 months ago by u/karma_irrelevant

reading receptor threads from 2024 and half of it aged badly

Explainerbranch of 5 comments

Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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5 comments, started 6 months ago
u/trialwatch_theoMOD746 points·6 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/camila_lindqvist392 points·6 months ago

Where does the mechanism data actually come from?

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u/aksel_palacios86 points·6 months ago

the 4-day half-life means week 4 is still ramp-up pharmacokinetically

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u/elin_lundgren48 points·6 months ago

rodent half-life tells you what to investigate, not what to expect in humans

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u/tomas_lundgren38 points·6 months ago

rodent half-life tells you what to investigate, not what to expect in humans

Disagree on that part. 98.7% and 96.2% on the same vial is normal.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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