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c/glp1science·submitted 11 months ago by u/runa_cabrera

reading half-life threads from 2024 and half of it aged badly

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Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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6 comments, started 11 months ago
u/piotr_grimaldi63 points·11 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/runa_cabreraOP23 points·11 months ago

The half-life is 12 hours, which means week 12 is genuinely still ramp-up. Week 14 is steady state.

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[removed]17 points·11 months ago

[removed by moderator]

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u/nadia_fonseca-15 points·11 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/runa_cabreraOP1 point·11 months ago

The appetite literature is interesting but rodent models do not scale linearly to human dosing.

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u/runa_cabreraOP34 points·11 months ago

gastric emptying is real and explains most early nausea

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