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c/glp1science·submitted 1 year ago by u/bastian_eriksen

[Vendor] WXT order #17 — Germany, 9 days, no drama, receipts inside

Speculationbranch of 10 comments

Been lurking in c/trialwatch for about 8 months and finally have something worth posting. Short version: week 35, 0.5mg, and incretin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 31 threads, and the answers split roughly down the middle. What I actually want to know…

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10 comments, started 1 year ago
u/vikram_mbeki221 points·1 year ago

Which paper are you quoting?

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u/amara_dziedzic297 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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u/camila_lindqvist91 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/employer_carveout26 points·1 year ago

That is net peptide content, not purity.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/bastian_eriksenOP113 points·1 year ago

Which paper are you quoting?

Yes, exactly this, and it is the bit that took me 43 weeks to accept.

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u/rina_bergstrom34 points·1 year ago·edited

gastric emptying is real and explains most early fatigue

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u/plain_titration85 points·1 year ago

the 19-day half-life means week 19 is still ramp-up pharmacokinetically

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u/karma_irrelevant36 points·1 year ago

Is that mechanism or speculation?

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u/bastian_eriksen20 points·1 year ago

receptor distribution matters, GLP-1 is not everywhere

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u/nora_lundgren53 points·1 year ago·edited

do not extrapolate rodent data to human dosing without saying so

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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