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c/glp1science·submitted 7 months ago by u/farid_kuipers

21 months in and pharmacology is still the thing I get wrong

Questionbranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/meta repeats that half-life is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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9 comments, started 6 months ago
u/devils_advocate_d59 points·6 months ago

Is that mechanism or speculation?

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u/nhs_waitlist_nUK15 points·6 months ago

receptor distribution matters, GLP-1 is not everywhere

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u/devils_advocate_d12 points·6 months ago

receptor distribution matters, GLP-1 is not everywhere

Adding to this: pharmacology is doing more work than the comment implies.

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u/marisol_kravchenko20 points·6 months ago·edited

the half-life is half-life, affects steady state timing

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u/emil_agyeman14 points·6 months ago

central appetite signalling is real but people overweight it

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u/noor_hovland7 points·6 months ago

mechanistic speculation is welcome if flaired as speculation

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u/the_poster_in_question_202644 points·6 months ago

Is that mechanism or speculation?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/emil_agyeman17 points·6 months ago

The incretin literature is interesting but rodent models do not scale linearly to human dosing.

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u/farid_kuipersOP6 points·6 months ago

amylin is not GLP-1, posts conflating them get corrected

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