receptor — 8 things I got wrong before I got it right
Confession thread, sort of.
I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 42 reads it before doing the same thing.
best — the order this archive was captured in
receptor distribution matters, GLP-1 is not everywhere
Strongly agree. Central appetite is real but people overstate it.
the 14-day half-life means week 14 is still ramp-up pharmacokinetically
Small correction: the trial was 12 weeks, not 23. Does not change your point but people will quote it.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
I love that this community will spend 40 comments on a detail.
Yes, exactly this, and it is the bit that took me 27 weeks to accept.
This is correct. Rodent data is investigational, not predictive.
Half-life is about 168 hours, so steady state lands around week 15–5. Practical consequence: what you feel in week 1 is not what that dose does.
Disagree. What you are describing is consistent with pharmacology, not with what you concluded.
- 1receptor distribution matters, GLP-1 is not everywhere4 comments in this branch · started by u/emil_agyeman