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c/glp1science·submitted 3 months ago by u/yusuf_ramos

receptor — my 19-week log, condensed into one table

Explainerbranch of 9 comments

Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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9 comments, started 3 months ago
u/formulary_fighterappeals283 points·3 months ago

I am going to push back on this slightly.

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[removed]213 points·3 months ago

[removed by moderator]

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u/slow_logbook68 points·3 months ago

This is correct. Rodent data is investigational, not predictive.

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u/whois_wanda0 points·3 months ago

gastric emptying is real and explains most early fatigue

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u/incretin_ivypharmacology36 points·3 months ago

rodent mechanism tells you what to investigate, not what to expect in humans

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u/camila_mensa17 points·3 months ago

incretin physiology is receptor, the mechanism layer

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u/nora_lundgren10 points·3 months ago

Not to be pedantic but incretin and gastric emptying are being used interchangeably and they are not interchangeable in real life.

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u/ismael_eriksen13 points·3 months ago

incretin physiology is receptor, the mechanism layer

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/bastian_eriksen29 points·3 months ago·edited

glucagon-receptor contribution is appetite for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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