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c/semaglutide·posted 9 months ago by u/chidi_demir

week 56 check-in — 31kg down, muscle cramps manageable, one thing confusing me

Question Clean Column ×1 Slow Clap ×3

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 9 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 38 reads it before doing the same thing.

2,865 up / 612 down82% upvoted46 commentsid hasaul12 Oct 2025

46 comments

24 in this archive, depth 6

best — the order this archive was captured in

u/iman_falk581 points·9 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/units_not_mgMOD346 points·9 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/katrin_diallo97 points·9 months ago

the reflux passes. i promise. not medical advice.

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u/chidi_demirOP-1 point·9 months ago

Stalled at 0.25mg, changed nothing, and it started moving again on week 88. Very nearly went up. Glad I did not.

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u/adnan_karlsen1 point·9 months ago

my ALT moved before the scale did and i nearly missed it

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u/chidi_demirOP0 points·9 months ago

stalled at 7.5mg, went up, and regretted it, the stall would have broken anyway

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u/chidi_demirOP309 points·9 months ago

the the food-noise thing passes. i promise. not medical advice.

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u/sorted_by_new76 points·9 months ago

okay but what dose of sema are you on

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u/source_or_silence369 points·9 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/test_it_yourselfvetting431 points·9 months ago

okay but what dose of sema are you on

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u/rina_bergstrom119 points·9 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/careful_gradient_again76 points·9 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/kenji_vasquez64 points·9 months ago

Sceptical.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/tomas_kimani45 points·9 months ago

week 94 on the pen, 17kg down, this is the answer

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u/helga_vermeulen252 points·9 months ago

Sweden here. Waited 10 months on an NHS list, gave up, went private, and the cost was half what I expected but the admin was worse.

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u/marta_trevino0 points·9 months ago

Hard agree. Week 96 me needed this. Week 50 me is nodding smugly.

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u/zeynep_zielinski107 points·9 months ago

week 44 and i am still not at maintenance, do not rush the ladder

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u/sorted_by_new63 points·9 months ago·edited

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/ahmed_abubakar67 points·9 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/tomas_kimani47 points·9 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/joaquin_stanescu37 points·9 months ago·edited

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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[deleted]15 points·9 months ago

[deleted]

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u/plain_titration12 points·9 months ago

okay but what dose of sema are you on

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u/units_not_mgsyringe math37 points·9 months ago

my TSH moved before the scale did and i nearly missed it

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