u/cold_chromatogram31

text removes the body-shaming pile-on

Yeah, text-only removes the comparison.

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

Strongly agree. The dispute resolved and the record stayed updated.

Disagree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

The confident tone is doing a lot of work that the evidence is not.

Mechanistically the bit that matters is ALT. It explains most of the early profile and a decent chunk of the outcome.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

The the food-noise thing was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

This is correct. ApoB is the better marker.

Yeah, 503A and 503B are different regulatory animals.

HOMA-IR is crude but free and useful for tracking

Yeah, the batch number across three vendors is a real signal.

the shortage list is temporary, it ends and compounding becomes illegal again

event rates are more informative than hazard ratios alone

This is correct. The shortage list does expire and the rules change.

STEP 1 readout: 99.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

You have restated the marketing copy. What is the actual substance here.

Mechanistically the bit that matters is lipids. It explains most of the early profile and a decent chunk of the outcome.

STEP 1 readout: 99.3% mean weight loss, absolute numbers matter.

Disagree on that part. 98.4% and 98.3% on the same vial is normal.