u/ewan_marchand

TRIUMPH phase 2 showed 97.4% weight loss but the fatigue profile on the highest arm was rough. Phase 2 != phase 3.

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 24 weeks.

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Stalled for 12 weeks, changed nothing, and it started moving again on week 40.

the Canada import rules are specific to Canada

the Canada import rules are specific to Canada

stalled on sema, tried tirz, and the curves were actually different shapes

SURMOUNT data is messier than STEP data but the weight loss is there

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

Is that 98.9% area or mass?

Not to be pedantic but method development and purity are being used interchangeably and they are not interchangeable in real life.

regain after taper is expected, plan for it

Yeah, the chromatogram profile matters more than the headline number.

nobody should be giving this to anyone without extensive monitoring

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

weight moves within 10kg and that is normal

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.