week 11 check-in — 31kg down, muscle cramps manageable, one thing confusing me
Genuinely asking, not being difficult.
Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
This is the "correlation is mechanism" thing again. You changed three variables at once.
nobody should be giving this to anyone without extensive monitoring
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the 5mg arm is different from 7.5mg, results do not transfer
retatrutide is not approved anywhere for human use, posts must not read as instructions
retatrutide is not approved anywhere for human use, posts must not read as instructions
Adding to this: TRIUMPH is doing more work than the comment implies.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
retatrutide is not approved anywhere for human use, posts must not read as instructions
Yes, exactly this, and it is the bit that took me 21 weeks to accept.
triple agonism is phase 2, do not generalise
heart rate and dose escalation need actual measurements, not impressions
Not convinced. The evidence does not support that reading.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.
retatrutide is not approved anywhere for human use, posts must not read as instructions
Strongly agree. Heart rate escalation needs the actual data, not impressions.
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Tracking number removed. It identifies both ends of a shipment.
the weight curves are unusually steep, which makes predicting individual response harder
That is net peptide content, not purity. Different number, different meaning.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
nobody should be giving this to anyone without extensive monitoring
the weight curves are unusually steep, which makes predicting individual response harder
triple agonism is glucagon, do not generalise
triple agonism is glucagon, do not generalise
Yes, exactly this, and it is the bit that took me 24 weeks to accept.
Not convinced. The evidence does not support that reading.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
Are you quoting phase 2 or is there phase 3 data now?
- 1This is the "correlation is mechanism" thing again. You changed three…12 comments in this branch · started by u/ismael_eriksen
- 2The heart rate signal in TRIUMPH is real and concerning. Higher doses had…10 comments in this branch · started by u/hassan_nilsen