c/retatrutide wiki

What this community is for

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

c/retatrutide was created on 6 Sep 2023 and currently has 64,900 members and 130 captured submissions. It sits in the busiest tier of the site, which mostly affects how fast a question gets answered rather than how well.

Rules, and why each exists

Community rules come first, then the six site-wide rules that apply everywhere on GLP Research Hub. Community rules are enforced by the moderators listed at the bottom of this page; site rules are enforced by everyone.

1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
3. Heart-rate and dose-escalation reports need actual measurements, not impressions.

And the site rules, which are short on purpose:

1. Independent community. Nobody here sells anything, and anyone who tries is banned.
2. Not medical advice. Describe what you did; never prescribe to a stranger.
3. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
4. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
5. No contact handles, wallet addresses or tracking numbers — they identify people.
6. Be recognisably decent. Disagree hard, insult nobody.

Terms you will see

Vocabulary that turns up constantly in c/retatrutide. Each links to the topic page, which collects every submission that touches it.

• retatrutide — triple GIP/GLP-1/glucagon receptor agonist, still in development.
• triple agonist — discussed frequently in this community — see the topic page for every submission that touches it.
• glucagon — discussed frequently in this community — see the topic page for every submission that touches it.
• TRIUMPH — discussed frequently in this community — see the topic page for every submission that touches it.
• phase 2 — discussed frequently in this community — see the topic page for every submission that touches it.
• dose escalation — discussed frequently in this community — see the topic page for every submission that touches it.

Start here

The twelve highest-scoring submissions in this community. Not necessarily the most correct — the most agreed-with, which is a different thing, and worth remembering when you read them.

1. [Results] 2 weeks, 46kg, and phase 2 was the hard part — 14k points, 45 comments, 2 years ago
2. switched from 2.5mg to 10mg and the early fullness got better, not worse — 13k points, 37 comments, 1 year ago
3. glucagon — my 7-week log, condensed into one table — 12k points, 37 comments, 1 year ago
4. what changed for me between week 65 and week 13 — 12k points, 35 comments, 2 years ago
5. [Results] 37 weeks, 16kg, and phase 2 was the hard part — 9.9k points, 50 comments, 1 year ago
6. unpopular opinion: retatrutide is massively overrated — 8.7k points, 68 comments, 2 years ago
7. [Lab] 5th independent test on QSC, and the trend is the interesting part — 8.5k points, 16 comments, 1 year ago
8. [Lab] 10th independent test on QSC, and the trend is the interesting part — 8.4k points, 46 comments, 1 year ago
9. 12 months in and triple agonist is still the thing I get wrong — 8.3k points, 41 comments, 2 years ago
10. does retatrutide actually matter or is it forum lore at this point — 8.1k points, 25 comments, 2 years ago
11. triple agonist: the version I wish someone had shown me in week 1 — 8k points, 13 comments, 2 years ago
12. does glucagon actually matter or is it forum lore at this point — 7.8k points, 42 comments, 11 months ago

Asked constantly

• the glucagon arm is why the appetite effect feels different
• reta made me not want food OR water and that is its own problem
• [Question] why is reta purity testing so much more variable between labs
• the dose escalation thing finally clicked for me and I want to write it down
• [Question] how do you actually verify dose escalation
• [Question] how do you actually verify triple agonist
• [Vendor] WXT order #24 — Germany, 21 days, no drama, receipts inside
• help me understand glucagon, I have read the wiki twice
• [Question] dose escalation — what am I missing here
• what changed for me between week 30 and week 79

If your question is on that list, read the answers there first. If it is not, ask it — that is what the community is for, and "this has been asked" is only a helpful reply when it comes with a link.

Who runs this

Moderation here is done by volunteers who also post as normal members. They are not clinicians, not vendors, and not paid.

• u/reta_and_regret — Went too fast on retatrutide. Learned. Posting the whole embarrassing arc.
• u/trialwatch_theo — I read the supplementary appendix so you do not have to. Pre-registration or it is a hypothesis.
• u/incretin_ivy — GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.
• u/ledger_mod — c/vendorvetting + c/scamalerts mod. Every claim needs a receipt or it gets a [needs source] flair.