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c/retatrutide·posted 2 years ago by u/bastian_ekstrom

does retatrutide actually matter or is it forum lore at this point

Trial Data Clean Column ×8 Slow Clap ×1 Well Actually ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

9,046 up / 969 down90% upvoted25 commentsid giua1w17 Jul 2024

25 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/reta_and_regretMOD1.8k points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/ewan_marchand2.6k points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/rohan_cardoso4k points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/naomi_erdogan2.7k points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/quiet_moderatormod-9 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

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u/bastian_ekstromOP1 point·2 years ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/soren_nkemelu1 point·2 years ago

Small correction: the trial was 22 weeks, not 16. Does not change your point but people will quote it.

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u/arne_amankwah1 point·2 years ago

Small correction: the trial was 22 weeks, not 16.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/bastian_ekstromOP1 point·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/marta_vanhecke1.1k points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/bastian_ekstromOP661 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/aa_analysis_andy594 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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[removed]439 points·2 years ago

[removed by moderator]

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u/reflux_report312 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
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