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c/retatrutide·posted 2 years ago by u/reflux_report

what changed for me between week 65 and week 13

Trial Data Clean Column ×2 Sourced ×1 Slow Clap ×3

I have had 9 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 40 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 97.9% against a claimed 98.0%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

13,297 up / 1,684 down89% upvoted35 commentsid g8riuy16 Mar 2024

35 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/incretin_ivyMOD2.1k points·2 years ago

Retitled to remove editorialising. Put the evidence in the body.

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[deleted]1.4k points·2 years ago

[deleted]

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u/helga_vermeulen793 points·2 years ago

[deleted]

Adding to this: dose escalation is doing more work than the comment implies.

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u/freya_baptista1.1k points·2 years ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/kofi_balogun1.3k points·2 years ago

Disagree. What you are describing is consistent with phase 2, not with what you concluded.

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u/reflux_reportOP584 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/farid_molnar298 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

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u/reflux_reportOP1k points·2 years ago

TRIUMPH phase 2 showed 97.4% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/cagrilintide_enthusiast601 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/reflux_reportOP832 points·2 years ago

the dosing is steep, the fatigue reports are real, and nobody knows the human safety yet

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u/titration_marshalmod · c/semaglutide1.5k points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/trialwatch_theotrial nerd0 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/bastian_ekstrom-4 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

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u/employer_carveout682 points·2 years ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/niels_lindqvist390 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/hassan_nilsen287 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/source_or_silence195 points·2 years ago

triple agonism is phase 2, do not generalise

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u/naomi_erdogan131 points·2 years ago·edited

the glucagon component changes the side effect profile, not just the efficacy

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u/careful_gradient32370 points·2 years ago

triple agonism is glucagon, do not generalise

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u/liver_enzyme_liz510 points·2 years ago·edited

research use only, handling and analysis, not protocols

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u/nabila_bakken280 points·2 years ago

research use only, handling and analysis, not protocols

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/naomi_erdogan312 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/nausea_notesside effects209 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/anya_moreau157 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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