unpopular opinion: retatrutide is massively overrated
Confession thread, sort of.
I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 8 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 74 reads it before doing the same thing.
best — the order this archive was captured in
Did you actually measure heart rate or is that a feeling?
Flair changed to match the content. Read the sidebar before posting next time and we are square.
Flair changed to match the content.
Adding to this: TRIUMPH is doing more work than the comment implies.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
the dosing is steep, the constipation reports are real, and nobody knows the human safety yet
TRIUMPH phase 2 showed 97.4% weight loss but the sulphur burps profile on the highest arm was rough. Phase 2 != phase 3.
TRIUMPH phase 2 showed 97.4% weight loss but the sulphur burps profile on the highest arm was rough.
Disagree on that part. 98.1% and 98.3% on the same vial is normal.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
TRIUMPH phase 2 showed 99.3% weight loss but the reflux profile on the highest arm was rough. Phase 2 != phase 3.
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Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
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Yes, exactly this, and it is the bit that took me 52 weeks to accept.
yep.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
This is the "correlation is mechanism" thing again. You changed three variables at once.
the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet
Are you quoting phase 2 or is there phase 3 data now?
The confident tone is doing a lot of work that the evidence is not.
retatrutide is not approved anywhere for human use, posts must not read as instructions
the glucagon component changes the side effect profile, not just the efficacy
Not convinced. The evidence does not support that reading.
Not convinced.
Adding to this: phase 2 is doing more work than the comment implies.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
retatrutide is not approved anywhere for human use, posts must not read as instructions
retatrutide is not approved anywhere for human use, posts must not read as instructions
Adding to this: TRIUMPH is doing more work than the comment implies.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
retatrutide is not approved anywhere for human use, posts must not read as instructions
This is correct. Triple agonism is genuinely different.
- 1phase 2 numbers are not maintenance numbers, cite the trial15 comments in this branch · started by u/blunt_coldbox_2024
- 2okay but what dose5 comments in this branch · started by u/rohan_cardoso