unpopular opinion: retatrutide is massively overrated
Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 8 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…
phase 2 numbers are not maintenance numbers, cite the trial
This is the "correlation is mechanism" thing again. You changed three variables at once.
the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet
Are you quoting phase 2 or is there phase 3 data now?
The confident tone is doing a lot of work that the evidence is not.
retatrutide is not approved anywhere for human use, posts must not read as instructions
the glucagon component changes the side effect profile, not just the efficacy
Not convinced. The evidence does not support that reading.
Not convinced.
Adding to this: phase 2 is doing more work than the comment implies.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
retatrutide is not approved anywhere for human use, posts must not read as instructions
retatrutide is not approved anywhere for human use, posts must not read as instructions
Adding to this: TRIUMPH is doing more work than the comment implies.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
retatrutide is not approved anywhere for human use, posts must not read as instructions
This is correct. Triple agonism is genuinely different.