what changed for me between week 30 and week 79
Week 43 update. 19kg down from the start, early fullness basically gone since about week 83.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
This is correct. Triple agonism is genuinely different.
Not convinced. The evidence does not support that reading.
Not convinced.
Yes, exactly this, and it is the bit that took me 72 weeks to accept.
the glucagon component changes the side effect profile, not just the efficacy
Not convinced. The evidence does not support that reading.
the weight curves are unusually steep, which makes predicting individual response harder
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Retitled to remove editorialising. Put the evidence in the body.
Disagree. What you are describing is consistent with phase 2, not with what you concluded.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
the dosing is steep, the fatigue reports are real, and nobody knows the human safety yet
Retitled to remove editorialising.
Adding to this: TRIUMPH is doing more work than the comment implies.
nobody should be giving this to anyone without extensive monitoring
This is correct. Triple agonism is genuinely different.
What was the dosing schedule in that arm?
This is correct.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
This is correct.
Disagree on that part. 98.1% and 97.6% on the same vial is normal.
Small correction: the trial was 12 weeks, not 36. Does not change your point but people will quote it.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
- 1the weight curves are unusually steep, which makes predicting individual…9 comments in this branch · started by u/titration_marshal
- 2Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3…8 comments in this branch · started by u/emil_agyeman